RESUMO
La enfermedad de Alzheimer es la causa más común de demencia en la población anciana. Actualmente no hay tratamientos efectivos para prevenir o retrasar el curso natural de dicha enfermedad. Numerosos estudios han proporcionado información de los procesos moleculares que subyacen en el envejecimiento biológico y, quizás más importante aún, de las posibles intervenciones para retrasar el envejecimiento y promover la longevidad saludable en sistemas modelo de laboratorio. La cuestión principal tratada en esta revisión es si una intervención que tiene propiedades antienvejecimiento puede alterar la aparición y/o progresión de la enfermedad de Alzheimer, una enfermedad en la que la edad es el mayor factor de riesgo. Diferentes intervenciones antienvejecimiento han demostrado prevenir (y posiblemente restaurar en algunos casos) varios parámetros reconocidos como síntomas centrales para el desarrollo de la enfermedad de Alzheimer. Además, se están dando los primeros pasos hacia la traslación de estos descubrimientos de laboratorio a aplicaciones clínicas (AU)
Alzheimer's disease is the most common cause of dementia in the elderly population. Currently, there are no effective treatments to prevent or delay the natural course of the disease. Numerous studies have provided information about the molecular processes underlying biological ageing and, perhaps more importantly, potential interventions to slow ageing and promote healthy longevity in laboratory model systems. The main issue addressed in this review is whether an intervention that has anti-ageing properties can alter the appearance and/or progression of Alzheimer's disease, a disease in which age is the biggest risk factor. Different anti-ageing interventions have been shown to prevent (and in some cases possibly restore) several parameters recognised as central symptoms to the development of Alzheimer's disease. In addition, they are taking the first steps towards translating these laboratory discoveries into clinical applications (AU)
Assuntos
Humanos , Animais , Doença de Alzheimer/tratamento farmacológico , Envelhecimento , Demência/tratamento farmacológico , Angiopatia Amiloide Cerebral/fisiopatologia , Modelos Animais de Doenças , Placa Amiloide/tratamento farmacológico , Peptídeos beta-Amiloides/antagonistas & inibidoresRESUMO
Alzheimer's disease is the most common cause of dementia in the elderly population. Currently, there are no effective treatments to prevent or delay the natural course of the disease. Numerous studies have provided information about the molecular processes underlying biological ageing and, perhaps more importantly, potential interventions to slow ageing and promote healthy longevity in laboratory model systems. The main issue addressed in this review is whether an intervention that has anti-ageing properties can alter the appearance and/or progression of Alzheimer's disease, a disease in which age is the biggest risk factor. Different anti-ageing interventions have been shown to prevent (and in some cases possibly restore) several parameters recognised as central symptoms to the development of Alzheimer's disease. In addition, they are taking the first steps towards translating these laboratory discoveries into clinical applications.
